Aesthetics research

PMID: 40318363

J Plast Reconstr Aesthet Surg. 2025 Apr 20;105:270-280. doi: 10.1016/j.bjps.2025.04.027. Online ahead of print.

ABSTRACT

BACKGROUND: The increasing popularity of minimally invasive soft tissue filler injections has been accompanied by a significant rise in filler reversal procedures, highlighting the concerns regarding adverse effects, including the facial overfilled syndrome (FOS). This trend suggests a growing need to understand individual facial regions contributing to FOS and their influence on patient perception.

OBJECTIVE: To investigate the influence of exaggerated volumization of facial regions on the perceptions of attractiveness and gender traits using eye-tracking and survey methods to better understand FOS.

METHODS: A total of 50 volunteers (30 women and 20 men) rated frontal images of different modified facial regions (i.e., eyes, cheeks, and lips) and the combination thereof on 5-point Likert scales for attractiveness, unattractiveness, masculinity, and femininity. Their gaze patterns and eye movements were analyzed using eye-tracking technology.

RESULTS: Elevating the lateral canthal angle sharply reduces the attractiveness in male and female faces. Accentuating the zygomatic arch generally decreases attractiveness and masculinity, particularly in men, while slightly increasing femininity. Lip volumization in women marginally increases attractiveness without significantly altering femininity. In combined modifications, the decrease in attractiveness is predominantly driven by the eye modification aspect, leading to the most substantial decline in the perceived attractiveness and gender-specific traits.

CONCLUSION: Certain facial modifications such as lip enhancement may increase attractiveness, while cheek enhancements may increase femininity. However, most alterations, particularly those involving the eyes or combinations of treatments, generally decrease attractiveness and impact the perceptions of femininity and masculinity. This underscores the need for balanced aesthetic treatments to prevent overcorrection.

PMID: 40316113

Int J Biol Macromol. 2025 Apr 30:143743. doi: 10.1016/j.ijbiomac.2025.143743. Online ahead of print.

ABSTRACT

In this study, we developed a novel biocompatible wound scaffold by encapsulating Barijeh (Bar), a plant-derived antibacterial compound, with niosome (Nio). The Nio-Bar formulation was incorporated into a chitosan (CS) and alginate (AL) hydrogel mixture, followed by 3D printing to create a three-dimensional scaffold, namely Nio-Bar@CS-AL. The obtained scaffold showed notable degradation, reaching 68 % (w/w) within 14 days. Nio-Bar@CS-AL displayed strong antibacterial activity and led to a >5-log reduction of both Pseudomonas aeruginosa and Staphylococcus aureus, far surpassing the performance of CS-AL scaffolds. Further, it effectively reduced biofilm formation by 74 %-80 % for both pathogens, and showed no cytotoxicity toward human fibroblast (HFF) cells, ensuring safety for wound application. In an in vivo murine wound model, Nio-Bar@CS-AL facilitated over 90 % wound healing after 10-day. Tissue integration was signaled by a twofold increase of TGF-β expression and a reduction of IL-6 expression to near-baseline levels, thereby mitigating inflammation. Histopathological analysis revealed a much higher collagen deposition, a key indicator of effective healing, in scaffold-treated wounds compared to the control. These results suggest that Nio-Bar@CS-AL holds promising clinical potential for treating wound infections and defects, offering a multifaceted strategy to improve wound healing outcomes.

PMID: 40293815

Aesthet Surg J. 2025 Apr 28:sjaf061. doi: 10.1093/asj/sjaf061. Online ahead of print.

NO ABSTRACT